Prurigo nodularis
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ReferencesPrurigo nodularis hè una cundizione di a pelle di longa durata, carattarizata da parechji bumps fermi è noduli, di solitu truvati nantu à e parti esterne di i bracci è i gammi. Questi bumps ponu varià in culore, da u tonu di carne à u rosa, è sò intensamente pruriginosi. Pò affettà e persone di ogni età è sò spessu ligati à altre cundizioni di a pelle chì causanu pruritu crònicu, cum'è a dermatite atopica. L'opzioni di trattamentu includenu medicazioni anti‑pruritu forti, droghi chì affettanu u sistema immunitariu, è medicazioni chì miranu à u sistema nervosu. A gestione di u prurigo nodularis generalmente implica una terapia à longu andà.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
U trattamentu generalmente implica l'usu di creme o iniezioni di steroidi nantu à a zona affettata. In i casi più severi o resistenti, trattamenti cum'è terapia di luce o medicazione chì sopprimenu u sistema immune ponu esse necessarii. Talidomide è lenalidomide sò opzioni per i casi severi, ma ponu avè effetti serii. Trattamenti più recenti (opioid receptor antagonists, neurokinin-1 receptor antagonists) mostranu una promessa in u trattamentu di prurigo nodularis cù menu effetti secundari rispetto à Talidomide o Lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo hè una cundizione di a pelle caratterizzata da pruritu longu (durata più di 6 settimane), lesioni di a pelle da scratch (graffi) è una storia di graffi frequenti. Implica neuroinflammation (infiammazione neuro) è fibrosi in a pelle.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis hè un prublema di a pelle di longa durata, marcatu da noduli pruriginosi. Ùn sapemu micca esattamente a causa, ma pare chì i prublemi immuni è nervosi ghjucanu un rolu in u ciclu di prurito‑scratch. Avà, ùn ci sò micca trattamenti appruvati da a FDA US specificamente per prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Trattamentu - Drugs OTC
Lavà a zona lesa cù sapone ùn aiuta micca è pò aggravà. L'unguentu steroide OTC pò aiutà à allevà i sintomi, ma di solitu bisognu di esse appiecatu per parechje settimane per vede un miglioramentu. Continuà à piglià antihistaminichi aiuta ancu à allevà u pruritu.
#OTC steroid ointment
#OTC antihistamine
○ Trattamentu
#Intralesional triamcinolone injection